At Columbia Biosciences, we provide scalable, analytically-verified biotin and Sulfo-Tag conjugation services for pharma, CRO, and diagnostic partners. The accuracy of biomolecule labeling, particularly with biotin and Sulfo-Tag reagents, directly impacts assay sensitivity, diagnostic performance, and regulatory compliance. We combine proven conjugation chemistry with rigorous analytical characterization and scalable manufacturing to deliver consistent, high-quality conjugates that meet the demanding needs of our global pharma and CRO clients.

Biotin & Sulfo-Tag Conjugation Capabilities at a Glance

Precision Biotinylation

Biotin conjugation supports a wide array of immunoassays and affinity-based platforms. We maintain strict control over degree of labeling (DoL) and purity to ensure reproducibility at scale.

• In-house control of all variables at our U.S. facility
• Consistent 3-7 biotin/molecule labeling range
• HPLC and LC-MS validation available for every lot

Sulfo-Tag Conjugation for High-Sensitivity Assays

Sulfo-Tag labels offer strong signal-to-noise performance across a variety of high-sensitivity assay platforms. As with biotin, maintaining consistent labeling density and site specificity is critical for scale-up and downstream reproducibility.

• Custom protocols for antibodies and detection proteins
• Batch-to-batch consistency across production runs
• LC-MS and HPLC QC available to confirm Degree of Labeling and residual free label content

Built for Biotech and CRO Demands

• Responsive timelines and expert consultation
• Transparent documentation with every order
• Flexible formats and labeling densities available
• All conjugations performed in the U.S.A. (Frederick, MD)

Let’s Get Started

Whether you’re preparing a pilot study or scaling a regulated workflow, our team is ready to deliver custom, QC-backed conjugates that meet your specifications.

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