Custom Conjugation

Why Choose Columbia Biosciences for Your Next Custom Conjugation?

  • Rapid turnaround time – 10-14 days, expedited 7 day service also available
  • Consistent and reproducible – detailed batch records & QC testing to ensure successful scale-up
  • Wide range of experience including fluorescent dyes, enzymes, proteins, haptens, and PEG 
  • Flexible – we provide custom conjugation services for both research and commercial applications
  • Experienced team – over 20 years of antibody and protein conjugation experience
  • Documentation – Certificate of Analysis for every custom conjugate includes concentration, F/P ratio and fluorometry
  • Scale up capabilities – microgram to gram scale
  • Trusted Partner – Custom conjugation service provider to most of the largest pharmaceutical companies

Functional Target Possibilities:

  • Immunoconjugates (Whole and Reduced IgG antibodies)
  • Proteins/Peptides
  • Nucleic Acids
  • Small Molecules (Fluorescent Dyes, Biotin)
  • Microparticles
  • Functionalized Polymers

Examples of Common Conjugation Partners:

  • Fluorophores
  • Small Molecules 
  • Proteins 
  • Enzymes
  • Oligonucleotides

Examples of Available Conjugation Chemistries
Targeted Groups:

  • Amines (Succinimidyl ester, Isothiocyanate)
  • Carboxylic acids (Carbodiimides)
  • Thiols (Maleimides, Haloacetimides)
  • Aldehydes (Hydrazines/Hydrazides, Reductive Amination)
  • Carbohydrates
  • Bioorthogonal (Azide-Alkyne, CuAAC and SPAAC)

For a flyer you can download and print, click here.

For general inquiries regarding our custom conjugation services, please fill out the form below.