Detection of wild type (blue) or N297A human IgG1. Target antibodies (2.5 µg/ml) were directly bound to ELISA plate wells and then incubated with indicated amount of purified mouse anti-human IgG1(N297A) Mab. After 2h’ incubation and plate washing the bound murine Mab were detected with goat anti-mouse HRP conjugate (HRP-112) and stabilized TMB substrate.

Mouse anti-human IgG1 (N297A):Biotin;100ug

$431.97

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Product Details

Clone: CB42
Monoclonal mouse anti-human IgG1(N297A) antibodies recognize mutated (N297A) Fc fragment of human IgG1. Do not cross-react with wild type or other mutations in the Fc region. Can be used for a highly specific detection of therapeutic recombinant antibodies that carry N297A mutation (TECENTRIQ®/Atezolizumab for example).

For a complete description of this antibody along with scientific data and validation studies, please click here.

Use:
Flow Cytometry/FACS
Size:
100ug
Concentration:
1mg/ml
Target:
Human IgG1(N297A)
Reactivity:
N297A mutation in the Fc region of human IgG1
Conjugate/Tag:
Biotin
Clonality:
Monoclonal
Isotype:
IgG
Form / Storage:
Conjugate supplied as liquid solution. Upon receipt, store at 2-8°C in the dark.
Technical Info:

Background: N297A mutation prevents glycosylation of human IgG1 Fc region, and thus abrogates immunoglobulin interaction with the Fc-receptors. This mutation is commonly introduced to recombinant therapeutic antibodies to prevent Ab-mediated adverse reactions in patients.

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