Columbia Biosciences has developed a unique expertise in genetic modification of primary human T lymphocytes. In these experiments, desired cell population is purified, expanded and transduced with high titer lentiviral vectors carrying the customer’s selected gene of interest. After transductions, cells are expanded further, tested for gene of interest expression and shipped to the customer as live ready-to-use cultures. Depending on the downstream application, genes of interest may include reporter genes (luciferase and/or fluorescent proteins), chimeric T-cell receptors and cytokines.
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